PDRN Power: How to Restore, Hydrate, and Protect Your Skin
- Mathilda Golding
- Aug 17
- 3 min read
If you’ve been searching for a way to strengthen your skin, repair damage, and improve overall hydration, PDRN-based treatments might be the solution you’ve been looking for. I’ve seen firsthand how these regenerative formulas can transform skin—and I want to share both my personal journey and my favorite ways to use them effectively.
What is PDRN?
PDRN (Polydeoxyribonucleotide) is a regenerative molecule derived from DNA fragments that helps promote cell repair, collagen production, and skin barrier restoration. It’s like giving your skin the nutrients it needs to heal, strengthen, and perform at its best.
PDRN is ideal for:
Dehydrated or compromised skin
Fine lines and early signs of aging
Post-treatment recovery (peels, microneedling, laser, etc.)
Redness, inflammation, or sensitive skin
My Personal PDRN & Skincare Journey
I want to share a bit of my own experience because it’s why I’m so passionate about PDRN and regenerative skincare. For years, I struggled with psoriasis, and finding the right products and treatments felt overwhelming. It wasn’t just about choosing the “right” creams, ointments or pills —it was about supporting my skin barrier consistently.
Through trial, error, and careful study, I discovered that combining PDRN-based serums and creams with cold plasma treatments made a tremendous difference. My skin became calmer, more resilient, and properly hydrated—and I no longer need biologic medications to manage flare-ups or daily irritations.
This personal experience drives how I guide my clients: it’s not just about using high-quality products—it’s about understanding your skin’s needs, layering correctly, and incorporating regenerative treatments that support barrier health and hydration.
How to Incorporate PDRN into Your Routine
Here’s how I recommend layering and using PDRN for the best results:
1. After Cleansing & Exfoliation: Apply a PDRN serum or ampoule while your skin is slightly damp. This primes the skin for deeper hydration and absorption.
2. Layering with Other Serums: If you use other serums (hydrating, peptide, or calming), PDRN products can often be layered without risk of cancellation, because they’re barrier-supportive and gentle.
3. Seal with Moisturizer: Lock in hydration and barrier protection with a PDRN-compatible cream or a gentle, hydrating moisturizer.
4. In-Studio Treatments: Cold plasma treatments enhance PDRN absorption and support cellular regeneration, making your at-home routine even more effective.
My Favorite PDRN Products
Here are the products I personally use and love for hydration, barrier support, and anti-aging benefits:
✨ PDRN Rejuvenating Line ✨
Toner, Ampoule, Moisturizer
Other PDRN Products I incorporate especially in hotter weather:
Moisture Tension Ampoule-Essence – Deep hydration, collagen support, and improved skin resilience.
N-PDRN Core Elastica Cream – Supports collagen production, improves firmness, and enhances elasticity.
💡 Tip: Even a few drops of serum or ampoule go a long way. Layering PDRN products correctly, followed by a supportive moisturizer, is the key to maximizing results.
Why PDRN Works
Barrier Support: Strengthens the skin’s natural defenses against environmental stressors.
Hydration: Deeply replenishes water levels in the skin, improving texture and elasticity.
Anti-Aging: Promotes collagen production for firmer, smoother skin.
Soothing & Regenerative: Reduces redness, irritation, and accelerates recovery after treatments.
Ready to Transform Your Skin with PDRN?
If you want personalized guidance on incorporating PDRN into your routine—including layering, product selection, and optional in-salon treatments—I can help you design a plan tailored to your skin’s unique needs.
📍 Book your personalized PDRN consultation at skinSPArations today
Your skin deserves intentional care—and I’m here to guide you every step of the way.
